synthesis and characterization of hydrazide-hydrazone derivatives of 3-pyridine carboxylic acid as antimycobac-terial tuberculosis agents
نویسندگان
چکیده
in this study synthesis of nicotinoyl hydrazone derivatives is investigated by introducing the nicotinicacidhydrazidepharmacophore into several molecules and screening for antimycobacterial activity. benzaldehyde derivatives react with nicotinicacidhydrazideto form nicotinoylhydrazones.the synthesized compounds were screened against m. tuberculosis h 37 rv, clinical isolates of m. tuberculosis and mdr clinical isolates of m. tuberculosis using the proportion test. the minimum inhibitory concentration (mic) of n' -(4-methylphenyl) nicotinicacidhydrazone and n' -(4-( n,n -dimethyl)phenyl)nicotinicacidhydrazone exhibited activity between 40 and 200µg/ml and could be a good start point to find new lead compounds against m. tuberculosis .
منابع مشابه
synthesis and characterization of hydrazide-hydrazone derivatives of 3-pyridine carboxylic acid as antimycobacterial tuberculosis agents
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عنوان ژورنال:
journal of reports in pharmaceutical sciencesجلد ۱، شماره ۱، صفحات ۶۰-۶۶
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