synthesis and characterization of hydrazide-hydrazone derivatives of 3-pyridine carboxylic acid as antimycobac-terial tuberculosis agents

نویسندگان

hadi adibi

saeed zaker

hamid monkaresi

چکیده

in this study synthesis of nicotinoyl hydrazone derivatives is investigated by introducing the nicotinicacidhydrazidepharmacophore into several molecules and screening for antimycobacterial activity. benzaldehyde derivatives react with nicotinicacidhydrazideto form nicotinoylhydrazones.the synthesized compounds were screened against m. tuberculosis h 37 rv, clinical isolates of m. tuberculosis and mdr clinical isolates of m. tuberculosis using the proportion test. the minimum inhibitory concentration (mic) of n' -(4-methylphenyl) nicotinicacidhydrazone and n' -(4-( n,n -dimethyl)phenyl)nicotinicacidhydrazone exhibited activity between 40  and 200µg/ml and could be a good start point to find new lead compounds against  m. tuberculosis .

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عنوان ژورنال:
journal of reports in pharmaceutical sciences

جلد ۱، شماره ۱، صفحات ۶۰-۶۶

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